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Deferiprone can protect the retinas of mice by entering the retina and removing iron from it, said Dunaief, whose lab is currently testing additional drugs to prevent iron accumulation in the eye. Dunaiefs research has shown that the oral iron chelator deferiprone may be a possible treatment for AMD if iron accumulation was one of the causes for its development. This means that ferritin is constantly being made no matter whether iron levels are high or low. Hyperferritinemia means high ferritin in the blood). Iron accumulates in the body with age because we continue to absorb it from our diets, but we excrete very little, Dunaief said. Oftentimes the storage protein for iron, ferritin, can reach the eye instead of the mineral itself. Serum ferritin : indicates the amount of iron stored in the body, via the protein ferritin. The macula, a small portion of the retina which is responsible for sharp and detailed vision, deteriorates over time when the retinal pigment epithelium (RPE) surrounding the macula oxidizes triggering an inflammatory response. Joshua Dunaief, professor of ophthalmology at the University of Pennsylvania School of Medicine.
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